Sm protein

The snRNPs are composed of small nuclear RNAs (snRNAs) - U U U Uand U- as well as a group of seven proteins known as Sm ribonucleoproteins . In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism.

LSm is a contraction of 'like Sm', because the . The SM protein derived from the spliced RNA joining BSLFto BMLFis much the most abundant protein. SM proteins are essential coagonists of SNARE proteins in fusion in that all intracellular SNARE-dependent fusion reactions require an SM .

Figure 2: Model of the SNARE–SM protein cycle during synaptic vesicle fusion. From A molecular machine for neurotransmitter release: . This family is found in Lsm (like-Sm) proteins, which have a core structure consisting of an open beta-barrel with an SH3-like topology. The association of Sm proteins with U small nuclear RNA (snRNA) requires the single-stranded Sm site (PuAU4–6GPu) but also is influenced by nonconserved . Epstein-Barr virus (EBV) SM protein is an essential nuclear protein produced during the lytic cycle of EBV replication.

SM is an RNA-binding protein with multiple . The Sm proteins are conserved in all three domains of life and are always associated with U-rich RNA sequences. Their proposed function is to mediate . Ab1366is a full length protein produced in Nativesyntheticaly and has been validated in ELISA, SDS-PAGE. Any of a family of proteins that participate in splicing of pre‐mRNA.

Seven members assemble into a ring, their inner surface binding the uridine‐rich region of . We now report that, in addition to their established roles as fusion accelerators, SM proteins Slyand Vpsdirectly shield SNARE complexes . These trans‐acting factors enable the faithful delivery of seven Sm proteins onto snRNA and the formation of the common core of snRNPs. GO ID: GO:0034719; Aspect: Cellular Component; Description: A protein complex formed by the association of several methylated Sm proteins with the SMN . GO ID: GO:0034715; Aspect: Cellular Component; Description: A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD .